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Research Update

Welcome to our monthly Research Update, available exclusively to IACLE and BCLA members to support your teaching and practice.

Issue 43 – July 2020

We begin this issue with a paper that investigates the time course of the onset and recovery of axial length changes in response to imposed defocus and then cover diverse topics from the contact lens world.

An Australian team determines the effect of water education in the form of “no-water” lens case stickers on water-contact behaviours and storage case contamination. A Chinese group compares optical quality in patients with dry eye before and after treatment. Another study attempts to find out if all dry eye symptoms in contact lens wear are induced by contact lenses. 

A Spanish team describes characteristics and habits of lens wearers purchasing lens over internet. A study investigates efficacy of pre-conditioning lens cases on bacterial biofilm formation and removal. And finally, we include a paper that examines the effect of sodium fluorescein on anterior eye surface measurements. 

Happy reading!!

The IACLE Education Team


Journals reviewed in this issue:

Nature Scientific Reports 10
Eye Published online
Clinical & Experimental Optometry Early view
Eye & Contact Lens 46:4
Contact Lens & Anterior Eye 43:4


Imposed defocus & onset & recovery of axial length changes

In this experiment, Delshad et al recruited 26 young adults to measure how quickly the eye length changed in response to both myopic and hyperopic defocus and also the recovery when the defocus was removed. Axial length was measured at baseline and every 10 minutes during 1 hour of exposure to three different levels of imposed monocular defocus. Recovery was measured for 20 minutes after blur removal. Their findings concluded that the human eye is able to detect and respond to the presence and sign of blur within minutes.

Sci Rep 2020; 10: 8322. DOI: 0.1038/s41598-020-65151-5. Read the full text


Compliance behaviour changes in contact lens wearers

To investigate the impact of behavioral education in the form of a simple visual infographic, the “no-water” sticker, on water-contact behaviors and storage case contamination of CL wearers, Arshad et al recruited 200 daily lens wearers in this prospective, masked, randomized controlled trial. The subjects were randomized to either receive a storage case with a “no-water” sticker (test) or without a “no-water” sticker (control). A no-water infographic on the contact lens case improved overall water-contact behaviors and reduced storage case endotoxin.

Eye 2020; DOI: 10.1038/s41433-020-1015-9. Read the abstract


Optical quality in patients with dry eye

In this prospective study Gao et al included 25 dry eye patients to evaluated changes in optical quality in patients with dry eye before and after treatment and identify potential indicators of dry eye-treatment efficacy. Examinations were performed before and after two weeks of treatment with hyaluronate in conjunction with fluorometholone eye drops. The optical quality of patients with dry eye improved after treatment. 

Sci Rep 2020; 10: 8322. DOI: 10.1038/s41598-020-65151-5. Read the abstract

Distinguishing CL induced dry eye from dry eye

The aim of this study conducted by Molina et al was to compare subjective and clinical outcomes in three study groups: (1) asymptomatic CL wearers (ASYM); (2) symptomatic CL wearers who became asymptomatic after lenses removed (CLIDE); and (3) CL wearers who were symptomatic both with and without lenses (DE). A battery of tests and questionnaires were administered to 92 full time CL wearers. Nearly half of symptomatic CL wearers had symptoms that were not directly CL-induced. It is critical to investigate symptomatic patients further and determine the underlying causes or contributing factors.

Eye & Contact Lens 2020;46:4 214-222. Read the abstract


Habits of internet contact lens purchasers

To investigate the characteristics and hygiene habits of CL wearers who acquire CLs over the Internet, as well as their awareness of modifiable risk factors (RFs), Mingo-Botín et al conducted this web-based survey among clients of an online CL sales platform. The authors found no differences in the degree of compliance or awareness of risk behaviors based on the purchase channel. However, the increasing number of CL wearers who begin by themselves acquiring CLs through the Internet, together with online exclusive purchase, is associated with a decrease in eye examination frequency, which implies a greater risk of complications.

Eye & Contact Lens 2020;46:4 208-213. Read the abstract


Bacterial biofilm and silver impregnated CL cases

Vijay et al evaluated the ability of silver impregnated CL storage cases to inhibit biofilm formation following 24 hours pre-conditioning with their complementary and noncomplementary lens care products. The authors found that Pre-conditioning of silver-impregnated lens cases inhibited initial bacterial biofilm formation. Synergi multipurpose solution (MPDS) was more effective than AQuify MPDS in removing bacterial biofilm in silver impregnated cases and tissue-wiping significantly improved biofilm removal.

Cont Lens Anterior Eye 2020;43:4 408-412. Read the full text


Sodium fluorescein & anterior eye surface measurements

To investigate the effect of sodium fluorescein (NaFl) dye on corneal topography and tear surface quality, Mulder et al measured ocular surface topography and quality of 57 eyes of 57 healthy individuals. One dose of NaFl resulted in increased reliability and consistency in corneal topography measurements using the E300 topographer, but 2 doses decreased reliability and consistency. Practitioners should be aware that tear film surface regularity and inferior-superior corneal power changed significantly following the addition of NaFl.

Cont Lens Anterior Eye 2020;43:4 402-407. Read the full text


© International Association of Contact Lens Educators 2020

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