Research Update

Research Update Issue 12

December 2017

It gives us immense pleasure to present the last issue of 2017. Surface lubricity has been considered as a main factor influencing contact lens comfort. In this issue, we include a study that isolates the contribution of surface properties to comfort. Another paper explores the association between characteristics of lid margins and tear film 

December 2017  
 
 
 
 

Welcome to our monthly research update
 
Welcome to Research Update, a new resource available to IACLE and BCLA members to support your teaching and practice. Each month we will send you a summary of some of the interesting findings appearing in peer-reviewed journals that month. Our aim is to help you keep up to date with the latest contact lens and anterior eye research, and to locate articles when you want to know more about a particular topic.
 
More information on Research Update and how to use it in your contact lens teaching here. Access archived issues via Member Login under Research.
 
 
 
Issue 12 – December 2017
 
It gives us immense pleasure to present the last issue of 2017. Surface lubricity has been considered as a main factor influencing contact lens comfort. In this issue, we include a study that isolates the contribution of surface properties to comfort. Another paper explores the association between characteristics of lid margins and tear film, and contact lens discomfort.

A group from South Korea evaluates the efficacy of eyelid management in meibomian gland dysfunction. We review a study that unearths pre-inflammatory signs in reusable and disposable lens wearers. We also report on a potential next-generation one-step hydrogen peroxide disinfection system with a case-based catalyst. And a group in Australia investigates whether initial performance of multifocal contact lenses predicts their short-term dispensing performance. Finally, we end the year by peeking into contact lens technology to 2020 and beyond.

We wish you a very happy new year 2018!

The IACLE Education Team
 
 
 
Journals reviewed in this issue  

  JOURNAL VOLUME AND ISSUE NUMBER
 
  Contact Lens & Anterior Eye Articles in press
  Clinical and Experimental Optometry 100:6, 100:5
  Optometry and Vision Science 94:11
  Eye & Contact Lens 43:6
 
 
 
 
 
 CL COMFORT
 

Effect of contact lens surface properties on comfort
In this randomized double-masked cross-over study, Vidal-Rohr et al attempted to isolate the influence of lens surface properties on contact lens comfort using an ultra-thin coating technology. Breakup time and ocular redness of 19 habitual CL wearers wearing the same monthly replacement soft lens with and without coating were evaluated. Symptoms were assessed after 1 week and 1 month of wear. Enhancing the physical surface properties of a soft contact lens was found to improve subjectively rated wearer comfort. This study suggests the importance of considering the coefficient of friction when fitting a contact lens.

Cont Lens Anterior Eye 2017;DOI:http://dx.doi.org/10.1016/j.clae.2017.09.009 Click here for full text

 
 
 
 
 
 CL COMFORT
 

Lid margins and tear film in contact lens discomfort
To determine whether characteristics of the eyelid margins, meibomian glands and tear film are related to contact lens discomfort, Siddireddy et al conducted this cross-sectional study among 30 existing daily wear soft CL wearers. Morphological irregularities of the meibomian glands and alterations to tear film secretions that affect tear evaporative dynamics were associated with discomfort among symptomatic wearers. Upper lid-wiper epitheliopathy (LWE), meibomian gland acini reflectivity and tear meniscus height showed significant correlations with comfort scores in both symptomatic and asymptomatic wearers.

Cont Lens Anterior Eye 2017;DOI:http://dx.doi.org/10.1016/j.clae.2017.10.004. Click here for full text

 
 
 
 
 
 EYELIDS
 

Meibomian gland squeezing for MGD
Lee et al carried out this prospective, intervention study to investigate the efficacy of eyelid management in meibomian gland dysfunction (MGD). Eyes of 32 subjects with moderate or severe MGD were treated with mechanical squeezing of meibomian glands, combined with eyelid scrubs and warm compresses. Tear film break-up time (TBUT), corneal and conjunctival staining, biomicroscopic examination, Ocular Surface Disease Index (OSDI) and tear film lipid layer thickness were evaluated before and after 1 month of treatment. This treatment could provide clinical benefits without serious adverse events.

Clin Exp Optom 2017;100:6 598-602. Click here for abstract

 
 
 
 
 
 PHYSIOLOGY
 

Pre-inflammatory signs and soft lens wear modality
This study by Chao et al compared the concentrations of tear cytokines and conjunctival cell morphology in 14 habitual daily disposable (DD) and 22 habitual reusable CL wearers in this cross-sectional single-visit study. Symptoms and ocular surface integrity were evaluated. Concentrations of tear cytokines were determined using multiplex assays. The study found higher tear cytokine concentration and conjunctival cell metaplasia in reusable CL wear as compared to DD CL wear. The balance of proinflammatory and anti-inflammatory cytokines may be helpful to assess the inflammatory status of the eye.

Optom Vis Sci 2017;94:11 1003-1008. Click here for abstract

 
 
 
 
 
 LENS CARE
 

Enhancing peroxide efficacy against Acanthamoeba
Kilvington & Winterton studied whether the addition of an iron-containing catalyst bound to a non-functional fabric matrix could enhance the antimicrobial efficacy of one-step H2O2 systems. Two systems (based on 3% H2O2) were tested with and without the presence of catalyst fabric, using Acanthamoeba cysts as challenge organism. After 6 hours’ disinfection, the number of viable cysts was determined. Both systems produced approximately 1-log kill without and 3-log kill in presence of the catalyst. The catalyst significantly increased the efficacy of one-step H2O2 disinfection systems against highly resistant Acanthamoeba cysts.

Optom Vis Sci 2017;94:11 1022-1028. Click here for abstract

 
 
 
 
 
 MULTIFOCALS
 

Predicting short-term performance of multifocal CLs
To investigate whether initial multifocal contact lens (MFCL) performance predicts short-term dispensing performance, Diec et al followed 55 subjects using two different brands of multifocal CL in a masked, crossover, clinical trial. Vision clarity, lack of ghosting at distance, and intermediate and near vision at day/night time were surveyed at fitting and assessment visits. Initial performance at fitting was not able to predict short-term performance of MFCLs. Subjective measures peaked at fitting and declined thereafter whereas acuity-based measures remained constant.

Eye & Contact Lens 2017;43:6 340-345. Click here for abstract

 
 
 
 
 
 TECHNOLOGY
 

Contact lens technology to 2020 and beyond
To gain insights into the way inventors are thinking about how contact lenses might be used in future, Papas reviewed over 300 patents submitted between January 2014 and February 2017. Vision correction, myopia, presbyopia and myopia control are likely to see new developments. Service delivery is the focus of some patents and they may hint at the way contact lens practice will be managed in the years to come. The other main areas where contact lenses will be applied include drug delivery, visual augmentation and biosensing.

Clin Exp Optom 2017;100:5 529-536. Click here for full text

 
 
 
 
 
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